Salmonella Research Today is a free monthly online journal that collates and summarizes the latest research about Salmonella, including details on salmonella typhimurium, food poisoning, infection, treatment.

H-NS, the genome sentinel.

Dorman CJ

Department of Microbiology, Trinity College Dublin, Dublin, Ireland. cjdorman@tcd.ie

Two recent reports have indicated that the H-NS protein in Salmonella enterica serovar Typhimurium has a key role in selectively silencing the transcription of large numbers of horizontally acquired AT-rich genes, including those that make up its major pathogenicity islands. Broadly similar conclusions have emerged from a study of H-NS binding to DNA in Escherichia coli. How do these findings affect our view of H-NS and its ability to influence bacterial evolution?

Published 16 January 2007 in Nat Rev Microbiol, 5(2): 157-61.
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