Salmonella Research Today is a free monthly online journal that collates and summarizes the latest research about Salmonella, including details on salmonella typhimurium, food poisoning, infection, treatment.

Treatment with anti-TNF alpha does not induce reactivation of latent Salmonella enterica serovar Typhimurium infection in C3H/HeN mice.

van Diepen A, Martina CA, Flierman R, Janssen R, van Dissel JT

Department of Infectious Diseases, Leiden University Medical Center, RC Leiden, The Netherlands.

Therapy with tumour necrosis factor-alpha (TNFalpha)-blocking agents is successful in treating inflammatory disorders, but carries an increased risk of manifest and reactivating infection with intracellular bacteria. In a mouse model of latent Salmonella typhimurium infection, neutralization of TNFalpha did not result in reactivation of infection, suggesting only a minor role for TNFalpha during latency of persistent Salmonella infection.

Published 20 April 2007 in Scand J Immunol, 65(5): 407-11.
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