Salmonella Research Today is a free monthly online journal that collates and summarizes the latest research about Salmonella, including details on salmonella typhimurium, food poisoning, infection, treatment.

Repression of intracellular virulence factors in Salmonella by the Hha and YdgT nucleoid-associated proteins.

Silphaduang U, Mascarenhas M, Karmali M, Coombes BK

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

The Hha/YmoA family of nucleoid-associated proteins is involved in gene regulation in enterobacteria. In Salmonella enterica serovar Typhimurium, virulence genes required for intracellular growth are induced following host cell invasion but the proteins responsible for repressing these genes prior to host cell entry have not been fully identified. We demonstrate here that Hha is the major repressor responsible for silencing virulence genes carried in Salmonella pathogenicity island 2 prior to bacteria sensing an intracellular environmental cue.

Published 18 April 2007 in J Bacteriol, 189(9): 3669-73.
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